Alisson is set to miss around six weeks to deal Liverpool a major blow ahead of their horror run, talkSPORT understands.
The 32-year-old suffered a hamstring injury in Saturday’s 1-0 away win at Crystal Palace.
Alisson was forced off at Palace on Saturday after picking up a hamstring injuryGetty
He had only just returned to action following a thigh issue in September, and is now set for a prolonged spell on the sidelines.
The Brazilian was spotted punching the floor in anger as he was forced off in the second half at Selhurst Park.
Back-up shot-stopper Caoimhin Kelleher will now replace Alisson between the sticks for the start of Liverpool’s nightmare run of fixtures.
Following the October international break, the Premier League leaders face Chelsea and Arsenal immediately afterwards.
A Champions League clash at RB Leipzig, who can now count on ex-Reds boss Jurgen Klopp as an adviser, is sandwiched in between those two crunch clashes.
Liverpool then face Brighton in back-to-back matches – first at the Amex Stadum in the Carabao Cup fourth round – before welcoming them to Anfield in the top-flight days later.
A blockbuster meeting with Bayer Leverkusen in the European Cup then follows, which will see Liverpool legend Xabi Alonso return to his former stomping ground.
The tough fixtures don’t stop there, with Aston Villa to then travel to Merseyside before the November international break.
Depending on how well Alisson recovers, he could be back to feature away at Southampton on November 24, before Liverpool’s next set of horror matches.
Alisson was spotted visibly gutted after going down in the second half at Selhurst Park
The Brazilian is no stranger for spells on the sidelinestalkSPORT
But should he suffer any possible setback during his rehab, it could see him miss the meeting with Real Madrid in matchday four of the revamped Champions League.
Liverpool then kick-off December with a mouthwatering match with Premier League champions Manchester City.
A midweek trip to Newcastle follows days later, with the Merseyside derby against Everton at Goodison Park taking place on December 7.
More to follow…